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Fausta Natella

Qualifica: RICERCATORE 

 

AST di afferenza: Scienze della Nutrizione

 

Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione

Roma, Italia,

via Ardeatina, 546

 

Email: natella@entecra.it

ATTIVITÀ DI RICERCA, INFORMAZIONE E PROMOZIONE

 

Svolgo attività di ricerca sul ruolo delle diverse componenti della dieta nella modulazione dello stress ossidativo nell’uomo. In particolare studio gli effetti biologici, le interrelazioni e le possibili ricadute sullo stato di salute e malattia di elementi dietetici preventivi (antiossidanti) e induttivi (grassi ossidabili e/o ossidati) di stress ossidativo.

La mia attività di ricerca si è sviluppata nel tempo secondo le seguenti linee sperimentali:

PUBBLICAZIONI RECENTI

  1. Natella F, Belelli F, Ramberti A & Scaccini C (2010) Microwave and traditional cooking methods: effect of cooking on antioxidant capacity and phenolic compounds content of seven vegetables. Journal of Food Biochemistry DOI: 10.1111/j.1745-4514.2009.00316.x
  2. Natella F, Lorrain B, Prasad AK, Parmar VS, Saso L, Scaccini C (2010) 4-Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation Biochimie doi.org/10.1016/j.biochi.2010.04.019
  3. Natella F, Ramberti A, Scaccini C Postprandial events as a trigger for redox unbalance: role of dietary lipid hydroperoxides and antioxidants In Valacchi G and Davis P eds “Oxidants in Biology: a question of balance”, Springer (2008).
  4. Natella F, Nardini M, Belelli F, Pignatelli P, Di Santo S, Ghiselli A, Violi F, Scaccini C. (2008) Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation. Br J Nutr 28:1-7.
  5. Natella F, Fidale M, Tubaro F, Urini F, Scaccini C. (2007) Selenium supplementation prevents the postprandial increase of atherogenic electronegative LDL. Nutrition Metabolism and Cardiovascular disease Feb 13 649-656.
  6. Nardini M, Natella F, Scaccini C (2007) Role of dietary polyphenols in platelet aggregation. A review  of the supplementation studies. Platelets 18(3): 224-243.
  7. Nardini M, Natella F, Ghiselli A, Scaccini C. The absorption and metabolism of phenolic acids from beer in man. In: Encyclopaedic Handbook of Beer in Health and Disease Prevention, Academic Press, Elsevier  (2007).
  8. Natella F, Nardini M, Belelli F, Scaccini C. (2007) Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am. J Clin Nutrition 86(3): 604-609.
  9. Nardini M, Natella F, Scaccini F, Ghiselli A. (2006) Phenolic acids from beer are absorbed and extensively metabolized in humans. J. Nutr. Biochem. Jan;17(1):14-22.
  10. Pignatelli P, Ghiselli A, Buchetti B, Carnevale R, Natella F, Germanò G, Fimognari F, Di Santo S, Violi F. (2006) Polyphenols synergistically inhibit oxidative stress in subject given red and white wine. Atherosclerosis  Sep;188(1):77-83.
  11. Natella F, Nardini M, Virgili F, Scaccini C. (2006) Role of dietary polyphenols in the platelet aggregation network- a review of the in vitro studies. Current Topics in Nutraceutical Research 4(1): 1-22.
  12. Virgili F, Ambra R, Muratori F, Natella F, Majewcz J, Minihane AM,  Rimbach G. (2003) Effect of oxidized low-density lipoprotein on differential gene expression in primary human endothelial cells. Antioxid Redox Signal 5(2) pag. 237-47.
  13. Ferruzza S, Scarino ML, Gambling L, Natella F, Sambuy Y (2003) Biphasic effect of iron on human intestinal Caco-2 cells: early effect on tight junction permeability with delayed onset of oxidative cytotoxic damage. Cell Mol Biol 49(1) pag. 89-99.
  14. Brunelli R, Greco G, Barteri M, Krasnowska E, Mei G, Natella F, Pala A, Rotella S, Ursini F, Zichella L, Parasassi T. (2003) One site on the apoB-100 specifically binds 17-b-estradiol and regulates the overall structure of LDL. FASEB J, 17(14):2127-9.

PUBBLICAZIONI DI PARTICOLARE RILEVANZA

  1. Natella F, Ghiselli A, Guidi A, Ursini F, Scaccini C. (2001) Red wine mitigates the postprandial increase of LDL susceptibility to oxidation. Free Rad. Biol. Med. 30 (9) pag. 1036-1044.